Great start today with 1A: It has everything (COSMOS), and it just kept on keepin' on after that. Very little garbage in this one, and what there was (ESA) (for example) was clued very well (44A: What's that to José?). Some answers seemed a little odd (ONEHORSEPLOW, FENCERAIL, HROSSPEROT), but there was nothing wrong with them. They're perfectly acceptable, just, I don't know... odd.
It seemed surprisingly straightforward for a Thursday. No rebuses, no circled letters, no trickery of any kind. Just a simple PRESTOCHANGEO (Magician's phrase ... or a hint to part of 18-, 25-, 34- and 41-Across) theme where each theme answer contains the letters P,R,E,S,T, and O in different arrangements. It took a while to figure it out, and the last theme clue to fall for us was the revealer, so knowing it didn't help the solving at all. It was interesting to learn that the name of that 18A: Classic cartoon in which "Kill da wabbit" is sung to a Wagner tune was WHATSOPERADOC. Who knew? Aside from Jeffrey Wechsler, I mean.
It seems every puzzle will have its OLIOs, its ICCs and its LUANAs (that last one almost killing us until we finally figured out 28D: Lux.'s place (EUR)!), but this puzzle was far heavier on clever clues and interesting answers. 59A: Best way to defuse a bomb, for example (CALMLY). It reminds us of Tom Lehrer's classic song "L-Y" and the line "As you walk along the street / A porcupine you meet / How do you shake his hand when he says hi? / Carefully... carefully... carful ... L-Y"