This was a strange solving experience. My final answer was NEWT, which was a weird aha moment, when I gathered suddenly that the "brew" referred to in 4D was a witches' brew, and the answer for 4D was not rYE but EYE. And that completed 1A: ?! (INTERROBANG) at the same time, a word I'd never heard of before but wish I had. What an excellent term.
In truth, I broke in with ATA after incorrectly entering "hold" for 8D: Restrain, as one's breath (BATE), and then guessed GROTTOES, off of which I was able to intuit SEEYOULATER and SWEETPOTATO. Then I had to work my way around the entire puzzle to end up back at the aforementioned 1A.
Every long answer in this puzzle shines, in my opinion. Two trios of 11-letter answers and two trios of 10-letter answers, and each is above average. ERYTHROCYTE is beautiful. HANDCRAFTS is great. LAPRESMIDI, an answer I needed no crosses for, is a nice reference to Debussy, but a piece I never had much use for myself. SAINTSDAYS is lovely, although isn't it true that every day is a Saint's day in the Catholic calendar? Certainly the two referenced (February 14 and March 17) are well-known for their individual saints.
There's a nice diagonal chunk of 5-letter answers in the middle, but unfortunately they're almost all of them plurals. JUICEBAR and VIBRATO are a couple of other nice answers. Clues I liked included 23A: Blood problem, maybe (FEUD) and 36A: Pair of elephants? (TUSKS). There were also some nice paired clues, including the violin duo of PEGS and VIBRATO, and the pair of heels (ROTTERS and RUPAUL).
There were a number of entries I didn't much like, including AWHIRL, ITI, DOABLE, and NRC. But they floated by in a sea of pleasurable stuff, so I overlook them.