Another good one - it's been a good week so far!
Who doesn't like anagrams? Sam Grana, that's who! (Just kidding, Sam, if you exist! (its an anagram)) But seriously, who? We're almost always fans of a goofy theme, and this seems just perfect for a Wednesday. SWORDHILT (17A: Weapon part that's out of this world?) was the least wacky, and because it was the first one I got, it made it difficult to see what was going on. I can no longer remember if I figured it out or if I just kept going and figured it out with the next one, but WETHOODS (17D: Drenched gangsters who are out of the woods?) is so madcap that it had to be figured out. And while we're over there, why is it ECOTONE (10D: Environmental transition area) and not "Eco-zone?" Well… ok… the internets tell me it's from eco + tonos (Greek) meaning "tension." So, it's a place where ecologies are in tension. OK, maybe now I'll remember it.
And one more thing over in that NE quadrant - POTOK (19A: Chaim who created Asher Lev). Never heard of him.
Oh, and speaking of ECOTONEs, I liked seeing JOHNMUIR (5D: Sierra Club founder) in the grid. I didn't particularly like seeing ARMPIT (48A: Lady Schick target) though. And although it didn't bother me, I was a little surprised to see NSFW (59D: Office-inappropriate, in web shorthand) in there.
So there were some oddities, and some partials, but the theme was good, and there's some very good non-theme fill (ASTHMA (54D: Inhaler user's malady), ORIGAMI (24A: Paper tiger, maybe), and others), so overall, a success!