Boy, I loved this puzzle. Thick, interesting corners, and a nicely done progression of "FL" followed by the five vowel sounds in order.
The puzzle started very quickly. I don't think I hit anything that I didn't fill in immediately until I was past TSETSEFLY (39A: Insect that causes sleeping sickness), but I was already loving it. EMBALMS (1D: Mummifies, e.g.), AMBIENT (3D: Surrounding, as sound), THRILLA (11D: ____ in Manilla (Ali/Frazier fight) (excellent), and SPANISHFLEA (25A: Theme music for TV's "The Dating Game") (I didn't know this previously, but it's perfect!) were all great. Also in the "didn't know, but hilarious" category was YUPPIEFLU (66A: Dismissive term for chronic fatigue syndrome).
OK, so it starts with the very crosswordsy ELAL, and there's more where that came from (SSTS, DELE, SOI, DSL, ISP, etc.), but there was plenty to offset it. Even the very odd YEST (18D: Tues. vis-à-vis Wed.) doesn't bother me. It's got a funny-ish clue, and like I said, there's more good than bad.
We've seen Ed Sessa's name a lot, but I never really have a good handle on him. I just searched his name on this blog, and we (and Colum) have reviewed nine of his puzzles, from every day of the week except Sunday, and I see that we've liked far more of them than we've disliked, and many we've liked quite a bit. I'm already looking forward to the next one.
p.s. Is it a problem that he clued two words that basically mean the same thing with the same clue?