This Saturday themeless is a mixed bag for me. Let us enumerate the ways.
First, I broke in at 4D: Genre of the 1970s movies "Foxy Brown" and "Three the Hard Way" (BLAXPLOITATION). I only needed the first movie title to get the answer, and with no crosses. Which was good, because I was getting none of the other answers in the NW corner without crosses. 1A: Emperor after Nero (GALBA) was empty for a very long time, and I eyed it with mistrust for a while before accepting the initial G. To my astonishment, as I read the New Yorker today, I found Galba referenced in a brief article about presidential candidates' hairstyles as compared to hairstyles of the ancient Romans. I'll give the piece of trivia a B.
I ended up moving to the SW next, where 54A: 1961 invasion locale (BAYOFPIGS) was another gimme. And this is, to me, the nit I have to pick with this puzzle. The difficult bits were difficult primarily because the references were simply unknown to me. I don't know EVIE Sands, and although I intuited GIL Scott-Heron, I didn't know him on his own. Maybe it's because Sands was primarily popular in the 60s and 70s, and The Revolution Will Not Be Televised was released in 1971. And then there's the IJSSEL. Whew! That's out there; the J was a guess, based on knowledge of how Dutch works. I'd be unsurprised if Horace and Frannie know it, given their recent jaunt through the Low Countries, but the rest of us? A big shrug. And ICEBEARS...
That being said, there's a lot of excellent parts to this puzzle as well. 17A: Willing to experiment, in a way (BICURIOUS) is excellent. 5D: What you find crawlers on (ALLFOURS) is a marvelous bit of unexpected simplicity in cluing. 19A: Vegan wrap? (FAUXFUR) is clever, although I wasn't misdirected at all. And how about 25A: Bad things to give away (ENDINGS)? No question mark, and I approve.
34A: Forum for seekers of faithful partners? (CHRISTIANMINGLE) is a great 15-letter answer, with a cute clue. It took me a while to get that answer because I'd incorrectly entered TAUTONmy at 9D (Taxonomic designation like Rattus rattus), thinking I was putting in "tautonomy". Of course, that didn't fit. I like the word TAUTONYM: I'd never come across it before.
My actual error came with DuH instead of DOH. I didn't get 46A: It rises out of a depression (JOBLOSS) at all. I didn't parse the economic term, thinking geologic instead. Maybe a "jubloss" was something like a "guyot". Yes, we know that term. Except not.
So some things that annoyed me, but over all, thumbs up.