Don't you love it when a mistake actually helps? It's so rare, especially on a Saturday.
Let me just say, before I get into all that, that I love this grid shape, with the vague S shape, with two open chunks going across just above and below the middle. The trio of 15-letter answers down the middle is a nice challenge that is met beautifully by Mr. Last.
So I got entree at 5A: ____ of Glamis (Shakespearean epithet) (THANE). I didn't need the parenthetical to get this reference to the Scottish play. Off of the H, at 6D: Modern-day "You can't please everyone", I immediately put in HAshtaG... figuring I'd get the ironic completion later on. As you can see, although I was wrong, I was in fact correct in two of those 7 letters after the H. Actually, now that I think about it, my mistake really didn't help me that much.
Actually, I had to leave all that and work in the lower section of the grid to get further purchase. 42A: Book with the line "My father can read big words, too. / Like Constantinople and Timbuktu" (HOPONPOP) was great - I remember that line with glee; after all, I was reading it to my kids. DOCTRINAL and GUAPOS are very nice as well, and it was those entries that got me THENOTORIOUSBIG. When I had ____WNHR at the end of 18A: Night-life industry bigwig (CLUBOWNER), I realized my mistake above, and corrected 6D to the excellent HATERSGONNAHATE.
Meanwhile, there is a ton of excellent fill elsewhere, including YOYOMA, BOLLYWOOD, PACKERS, and IDONTBITE. That last one I had a W in the place of the D which made the SW the final section to drop: I had _IOWE at 45D: Current path? (DIODE).
The Cher reference is a nice rebuttal to the recent fooforaw over Wednesday's 71A: Exasperated comment from a feminist (MEN). This clue is far more interesting and non-offensive. Still, my favorite is definitely 30A, because I love the reinterpretation of "stretcher" from the sense of a medical transport bed to a person who is stretching. And, plus, well, you know. Yoga pants. Nuff said.
1A: Coddle (BABY) is pretty good. B. I didn't love PDS, OTO, or KYD. Otherwise, thumbs up all around for me.