Pretty much an all around outstanding themeless puzzle today, in my humble opinion. I broke in with 3D: One might sense bitterness (TASTEBUD), and knew we were in for a fun time.
It was a playground for our favorite kind of clue, the non-question mark tricky kind. Just a few to note here: 5A: Trip ... or start a trip (SETOFF) - nice because I was definitely not thinking of that first definition of triggering as an alarm. 15A: Toy in a purse, perhaps (POODLE) - really outstanding. My mind was way far away from that as an answer. And how about 12D: Frequent losers at casinos (DEUCES)? Hah! I love it.
I almost forgot one of the best! 26D: They always proceed in a biased way (BISHOPS) - referring to the chess pieces, I assume. I hope. Or maybe it's a veiled commentary? I won't walk down that garden path.
The QMCs were less enjoyable, or maybe my opinion is colored by the unpleasantness at 26A. 46A: Diamond in the rough? (SANDLOT) is pretty good.
The long intersecting answers in the middle are all pretty good. I like SENIORPRANK and DEPECHEMODE, and any reference to LENAHORNE is a winner in my book.
Finally, two other references make this puzzle my favorite of the week so far. The first is to that classic of slapstick humor, Airplane! (TED). And of course, the greatest classical composer of all time gets a nod with 42D: B in music class? (BRAHMS). The other two Bs, Bach and Beethoven, are pretty good too. I guess.