Just look at that thick swath through the center of this one. Five nines and and two eights stepping down like wide stairs, pinned by nines, tens, and elevens. I don't construct puzzles, but it sure looks like an impressive feat.the Pogues. See also: TURK.
But let's not dwell on sad things. Let's look instead at the humor in the misfortunes of others - like OWS (Smart remarks?) and "Where many a drive ends, unfortunately" (WATERHAZARD). Heh.
ARM (Vaccine target) was both topical and misleading! Nice. And I loved the clue "Break" for DOMESTICATE. And speaking of clues, "Places where things are all tied up?" was funny for MARINAS. It's so true.
There were a few weirdos, like LACTEAL (Milk-producing), GOTEM ("Ha, fell right into my trap!"), and DESEX (Neuter), but overall not too much to PAY for a solid Saturday grid.