I dropped in MANCHESTERUNITED like I wrote the clue myself and SOUTHBYSOUTHWEST was no problem, but I did have to resort to the old sing-song pattern to get MISSISSIPPIDELTA spelled correctly. I did not go so far as the old 'M I crooked letter crooked letter I crooked letter crooked letter I humpback humpback I,' but, I could have. :) What do these three 16-letter theme answers have in common, you ask? Well, they hint at arrival and departure locales. Sweet.
I got a little hung up in the southeast because I first entered ASHcan instead of ASHBIN at 43D. and I am not familiar with actress DEBI Mazar of "Entourage," but I sorted myself out eventually.
I liked the anagram at 49A. Bush, or an anagram of BUSH plus one letter (SHRUB). Also enjoyed "Like the group you're in if you're out, for short" clue at 40D. (LGBT). And Applesauce meaning HOKUM is a new one on me (31A).
Horace and I agreed that CUESTA (Hill that's steep on one side and gentle on the other) was a bit of an outlier for a Tuesday. Some of the 18 three-letter words left a little to be desired, like TRA, TIL, and EDA, but not every answer can be one's PRIDEANDJOY.